Application | Comment | Organism |
---|---|---|
medicine | tuberculosis, TB, target of anti-tubercular agents | Mycobacterium tuberculosis |
Cloned (Comment) | Organism |
---|---|
- |
Mycobacterium tuberculosis |
Crystallization (Comment) | Organism |
---|---|
wild-type enzyme, S94A, I47T and I21V mutants in complex with NADH at resolutions of 2.3 A, 2.2 A, 2.0 A, 1.9 A, respectively | Mycobacterium tuberculosis |
Protein Variants | Comment | Organism |
---|---|---|
I21V | mutant, studied for understanding of the isoniazid drug resistance mechanism | Mycobacterium tuberculosis |
I47T | mutant, studied for understanding of the isoniazid drug resistance mechanism | Mycobacterium tuberculosis |
S94A | mutant, studied for understanding of the isoniazid drug resistance mechanism | Mycobacterium tuberculosis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
isoniazid | - |
Mycobacterium tuberculosis |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
104900 | - |
mutant I21V, estimated by gel-filtration chromatography | Mycobacterium tuberculosis |
108700 | - |
mutant S94A, estimated by gel-filtration chromatography | Mycobacterium tuberculosis |
115900 | - |
wild-type enzyme, estimated by gel-filtration chromatography | Mycobacterium tuberculosis |
118100 | - |
mutant I47T, estimated by gel-filtration chromatography | Mycobacterium tuberculosis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acyl-[acyl-carrier protein] + NAD+ | Mycobacterium tuberculosis | - |
trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Mycobacterium tuberculosis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acyl-[acyl-carrier protein] + NAD+ | - |
Mycobacterium tuberculosis | trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
homotetramer | - |
Mycobacterium tuberculosis |
Synonyms | Comment | Organism |
---|---|---|
2-trans enoyl-acyl carrier protein reductase | - |
Mycobacterium tuberculosis |
enoyl-ACP(CoA) reductase | - |
Mycobacterium tuberculosis |
enoyl-[acyl-carrier-protein] reductase | - |
Mycobacterium tuberculosis |
InhA | - |
Mycobacterium tuberculosis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | - |
Mycobacterium tuberculosis |