Crystallization (Comment) | Organism |
---|---|
crystals of FabI/NAD+ complex with (E)-N-methyl-N-(1-methyl-1H-indol-3-ylmethyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthydrin-3-yl)acrylamide diffract to 2.3 A | Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(E)-N-methyl-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)-N-(1,2,7-trimethyl-1H-indol-3-ylmethyl)acrylamide | 0.00007 mM, 50% inhibition | Haemophilus influenzae | |
(E)-N-methyl-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphtyridin-3-yl)-N-(1,2,7-trimethyl-1H-indol-3-ylmethyl)acrylamide | 0.00002 mM, 50% inhibition | Staphylococcus aureus | |
(E)-N-methyl-N-(1,2-dimethyl-1H-indol-3-ylmethyl)-N-methyl-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide | 0.000025 mM, 50% inhibition | Haemophilus influenzae | |
(E)-N-methyl-N-(1,2-dimethyl-1H-indol-3-ylmethyl)-N-methyl-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide | 0.00006 mM, 50% inhibition | Staphylococcus aureus | |
(E)-N-methyl-N-(1-methyl-1H-indol-2-ylmethyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide | 0.0006 mM, 50% inhibition | Haemophilus influenzae | |
(E)-N-methyl-N-(1-methyl-1H-indol-2-ylmethyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide | 0.00005 mM, 50% inhibition | Staphylococcus aureus | |
(E)-N-methyl-N-(1-methyl-1H-indol-3-ylmethyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide | 0.0004 mM, 50% inhibition | Haemophilus influenzae | |
(E)-N-methyl-N-(1-methyl-1H-indol-3-ylmethyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide | 0.0001 mM, 50% inhibition | Staphylococcus aureus | |
(E)-N-methyl-N-(1-methyl-1H-indol-3-ylmethyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide | 0.005 mM, 50% inhibition | Streptococcus pneumoniae | |
(E)-N-methyl-N-(2-methyl-1H-indol-3-ylmethyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide | 0.00013 mM, 50% inhibition | Haemophilus influenzae | |
(E)-N-methyl-N-(2-methyl-1H-indol-3-ylmethyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide | 0.00005 mM, 50% inhibition | Staphylococcus aureus | |
(E)-N-methyl-N-(2-methyl-1H-indol-3-ylmethyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide | 0.006 mM, 50% inhibition | Streptococcus pneumoniae | |
triclosan | 0.00007 mM, 50% inhibition | Staphylococcus aureus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Haemophilus influenzae | - |
- |
- |
Staphylococcus aureus | - |
- |
- |
Streptococcus pneumoniae | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
trans-2-dodecenoyl-ACP + NADH | - |
Staphylococcus aureus | dodecanoyl-ACP + NAD+ | - |
? | |
trans-2-dodecenoyl-[acyl-carrier protein] + NADH | - |
Escherichia coli | dodecanoyl-ACP + NAD+ | - |
? | |
trans-2-dodecenoyl-[acyl-carrier protein] + NADH | - |
Streptococcus pneumoniae | dodecanoyl-ACP + NAD+ | - |
? | |
trans-2-dodecenoyl-[acyl-carrier protein] + NADH | - |
Haemophilus influenzae | dodecanoyl-[acyl-carrier protein] + NAD+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
FabI | - |
Escherichia coli |
FabK | - |
Streptococcus pneumoniae |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | - |
Staphylococcus aureus | |
NADH | - |
Haemophilus influenzae | |
NADH | - |
Escherichia coli | |
NADH | - |
Streptococcus pneumoniae |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000023 | - |
(E)-N-methyl-N-(1-methyl-1H-indol-2-ylmethyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide | 30°C, pH 6.5 | Staphylococcus aureus | |
0.0000043 | - |
(E)-N-methyl-N-(1-methyl-1H-indol-2-ylmethyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide | 30°C, pH 6.5 | Haemophilus influenzae |