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Literature summary for 1.3.1.81 extracted from

  • Rios-Estepa, R.; Turner, G.W.; Lee, J.M.; Croteau, R.B.; Lange, B.M.
    A systems biology approach identifies the biochemical mechanisms regulating monoterpenoid essential oil composition in peppermint (2008), Proc. Natl. Acad. Sci. USA, 105, 2818-2823.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.3.1.81

Inhibitors

Inhibitors Comment Organism Structure
(+)-menthofuran weak competitive inhibition, in peppermint plants grown under low-light conditions, (+)-menthofuran is selectively retained in secretory cells and accumulated to very high levels of up to 20 mM, whereas under regular growth conditions, (+)-menthofuran levels remain very low, below 0.4 mM Mentha x piperita

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information kinetic data analysis, overview Mentha x piperita
0.04
-
 (+)-pulegone pH 6.6 Mentha x piperita

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 (+)-pulegone + 2 NADPH + 2 H+ Mentha x piperita branchpoint enzyme in essential oil biosynthesis (-)-menthone + (+)-isomenthone + 2 NADP+
-
 ?
additional information Mentha x piperita kinetic modeling and simulations of the developmental patterns of monoterpenoid essential oil accumulation in peppermint, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mentha x piperita
-
 cv. Black Mitcham
-

Purification (Commentary)

Purification (Comment) Organism
native enzyme partially by isolation of secretory cells from leaves Mentha x piperita

Source Tissue

Source Tissue Comment Organism Textmining
leaf
-
 Mentha x piperita
-
secretory cell
-
 Mentha x piperita
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 (+)-pulegone + 2 NADPH + 2 H+
-
 Mentha x piperita (-)-menthone + (+)-isomenthone + 2 NADP+
-
 ?
2 (+)-pulegone + 2 NADPH + 2 H+ branchpoint enzyme in essential oil biosynthesis Mentha x piperita (-)-menthone + (+)-isomenthone + 2 NADP+
-
 ?
additional information kinetic modeling and simulations of the developmental patterns of monoterpenoid essential oil accumulation in peppermint, overview Mentha x piperita ?
-
 ?

Synonyms

Synonyms Comment Organism
pulegone reductase
-
 Mentha x piperita

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.6
-
 assay at Mentha x piperita

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Mentha x piperita

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.3
-
 (+)-menthofuran pH 6.6 Mentha x piperita

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.15
-
 pH 6.6 Mentha x piperita (+)-menthofuran