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Literature summary for 1.3.1.8 extracted from

  • Sargueil, F.; Knoll, A.; Salles, J.; Garbay, B.; Cassagne, C.
    High metabolism and subsequent elongation of 3-hydroxyeicosanoyl-CoA in very-long- chain fatty acid deficient PNS of Trembler mice (1999), Neurosci. Lett., 273, 29-32.
    View publication on PubMed
Search for more literature for 1.3.1.8

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Mus musculus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
trans-2-eicosenoyl-CoA + NADPH Mus musculus enzyme is part of acyl-CoA elongase complex responsible for fatty acid elongation eicosanoyl-CoA + NADP+
-
 ?
trans-2-eicosenoyl-CoA + NADPH Mus musculus enzyme activity is higher in neurological Trembler mouse mutant than in wild-type eicosanoyl-CoA + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 wild-type and neurological er mouse mutant
-

Source Tissue

Source Tissue Comment Organism Textmining
peripheral nerve
-
 Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 60 days after birth enzyme activity is reduced to 0.27 nmol per min per mg of protein Mus musculus
0.00065
-
 11 to 26 days after birth of wild-type mice Mus musculus
0.00081
-
 mouse mutant, activity is independent on developmental stage Mus musculus
0.00267
-
 activity peak 17 days after birth of mutant mice Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
trans-2-eicosenoyl-CoA + NADPH
-
 Mus musculus eicosanoyl-CoA + NADP+
-
 ?
trans-2-eicosenoyl-CoA + NADPH enzyme is part of acyl-CoA elongase complex responsible for fatty acid elongation Mus musculus eicosanoyl-CoA + NADP+
-
 ?
trans-2-eicosenoyl-CoA + NADPH enzyme activity is higher in neurological Trembler mouse mutant than in wild-type Mus musculus eicosanoyl-CoA + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
trans-2-enoyl-CoA reductase
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Mus musculus