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Literature summary for 1.3.1.8 extracted from

  • Prasad, M.R.; Chiang, C.F.; Cook, L.; Cinti, D.L.
    Solubilization and purification of hepatic microsomal trans-2-enoyl-CoA reductase: evidence for the existence of a second long-chain enoyl-CoA reductase (1985), Arch. Biochem. Biophys., 237, 535-544.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
trans-2-hexenoyl-CoA competitive inhibition of crotonoyl-CoA reduction, but not of 2-trans-hexadecenoyl-CoA and 2-trans-decenoyl-CoA reduction Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0005
-
2-trans-hexenoyl-CoA
-
Rattus norvegicus
0.0011
-
2-trans-hexadecenoyl-CoA
-
Rattus norvegicus
0.01
-
NADPH
-
Rattus norvegicus
0.02
-
crotonyl-CoA
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
no information in the literature concerning reduction of cis-2-enoyl-CoA substrates, thus classification of rat enzyme according to EC 1.3.1.8 or EC 1.3.1.38 impossible
-

Purification (Commentary)

Purification (Comment) Organism
partial Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.54
-
partially purified Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-trans-decenoyl-CoA + NAD(P)H
-
Rattus norvegicus decanoyl-CoA + NADP+
-
?
2-trans-dodecenoyl-CoA + NAD(P)H
-
Rattus norvegicus dodecanoyl-CoA + NAD(P)+
-
?
2-trans-hexadecenoyl-CoA + NADPH
-
Rattus norvegicus hexadecanoyl CoA + NADP+
-
?
2-trans-hexenoyl-CoA + NAD(P)H
-
Rattus norvegicus hexanoyl-CoA + NADP+
-
?
2-trans-octenoyl-CoA + NAD(P)H
-
Rattus norvegicus octanoyl-CoA + NADP+
-
?
2-trans-tetradecenoyl-CoA + NADPH
-
Rattus norvegicus tetradecanoyl-CoA + NADP+
-
?
crotonyl-CoA + NAD(P)H
-
Rattus norvegicus butanoyl-CoA + NADP+
-
?
additional information NADPH specific trans-enoyl-CoA reductases isolated from rat liver microsomes and mitochondria impossible to classify according to EC 1.3.1.8 or EC 1.3.1.38 because no cis-isomers of 2-enoyl-CoA have been tested as substrates Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
trans-2-enoyl-CoA reductase
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH inactive with NADH Rattus norvegicus