Inhibitors | Comment | Organism | Structure |
---|---|---|---|
trans-2-hexenoyl-CoA | competitive inhibition of crotonoyl-CoA reduction, but not of 2-trans-hexadecenoyl-CoA and 2-trans-decenoyl-CoA reduction | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0005 | - |
2-trans-hexenoyl-CoA | - |
Rattus norvegicus | |
0.0011 | - |
2-trans-hexadecenoyl-CoA | - |
Rattus norvegicus | |
0.01 | - |
NADPH | - |
Rattus norvegicus | |
0.02 | - |
crotonyl-CoA | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Rattus norvegicus | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
no information in the literature concerning reduction of cis-2-enoyl-CoA substrates, thus classification of rat enzyme according to EC 1.3.1.8 or EC 1.3.1.38 impossible | - |
Purification (Comment) | Organism |
---|---|
partial | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
1.54 | - |
partially purified | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-trans-decenoyl-CoA + NAD(P)H | - |
Rattus norvegicus | decanoyl-CoA + NADP+ | - |
? | |
2-trans-dodecenoyl-CoA + NAD(P)H | - |
Rattus norvegicus | dodecanoyl-CoA + NAD(P)+ | - |
? | |
2-trans-hexadecenoyl-CoA + NADPH | - |
Rattus norvegicus | hexadecanoyl CoA + NADP+ | - |
? | |
2-trans-hexenoyl-CoA + NAD(P)H | - |
Rattus norvegicus | hexanoyl-CoA + NADP+ | - |
? | |
2-trans-octenoyl-CoA + NAD(P)H | - |
Rattus norvegicus | octanoyl-CoA + NADP+ | - |
? | |
2-trans-tetradecenoyl-CoA + NADPH | - |
Rattus norvegicus | tetradecanoyl-CoA + NADP+ | - |
? | |
crotonyl-CoA + NAD(P)H | - |
Rattus norvegicus | butanoyl-CoA + NADP+ | - |
? | |
additional information | NADPH specific trans-enoyl-CoA reductases isolated from rat liver microsomes and mitochondria impossible to classify according to EC 1.3.1.8 or EC 1.3.1.38 because no cis-isomers of 2-enoyl-CoA have been tested as substrates | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
trans-2-enoyl-CoA reductase | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | inactive with NADH | Rattus norvegicus |