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Literature summary for 1.3.1.8 extracted from

  • Bernert, J.T.; Sprecher, H.
    An analysis of partial reactions in the overall chain elongation of saturated and unsaturated fatty acids by rat liver microsomes (1977), J. Biol. Chem., 252, 6736-6744.
    View publication on PubMed
Search for more literature for 1.3.1.8

Activating Compound

Activating Compound Comment Organism Structure
additional information bovine serum albumin in assay mixture elevated the activity Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
2-trans-octadecenoyl-CoA without bovine serum albumin substrate-induced inhibition at 0.02-0.03 mM Rattus norvegicus
palmitoyl-CoA without bovine serum albumin substrate-induced inhibition at 0.02-0.03 mM Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 no information in the literature concerning reduction of cis-2-enoyl-CoA substrates, thus classification of rat enzyme according to EC 1.3.1.8 or EC 1.3.1.38 impossible
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-trans-8,11-eicosatrienoyl-CoA + NADPH fat-free dietary elevates the activity Rattus norvegicus 8,11-eicosadienoyl-CoA + NADP+
-
 ?
2-trans-hexadecenoyl-CoA + NADPH
-
 Rattus norvegicus hexadecanoyl CoA + NADP+
-
 ?
2-trans-octadecenoyl-CoA + NAD(P)H i.e. 2-trans-oleoyl-CoA Rattus norvegicus octadecanoyl-CoA + NAD(P)+
-
 ?
2-trans-octenoyl-CoA + NAD(P)H
-
 Rattus norvegicus octanoyl-CoA + NADP+
-
 ?
6,9-octadecadienoyl-CoA + NADPH fat-free dietary elevates the activity Rattus norvegicus ?
-
 ?
additional information NADPH specific trans-enoyl-CoA reductases isolated from rat liver microsomes and mitochondria impossible to classify according to EC 1.3.1.8 or EC 1.3.1.38 because no cis-isomers of 2-enoyl-CoA have been tested as substrates Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
2-trans-enoyl-CoA reductase
-
 Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.3
-
 in HEPES and Bicine buffer Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH inactive with NADH Rattus norvegicus