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Literature summary for 1.3.1.72 extracted from

  • Cho, S.Y.; Kim, J.H.; Paik, Y.K.
    Cholesterol biosynthesis from lanosterol: differential inhibition of sterol DELTA8-isomerase and other lanosterol-converting enzymes by tamoxifen (1998), Mol. Cells, 8, 233-239.
    View publication on PubMed
Search for more literature for 1.3.1.72

Inhibitors

Inhibitors Comment Organism Structure
tamoxifen inhibition mechanism and pattern, uncompetitive, 50% inhibition at 0.004 mM, cytotoxic in vivo, inhibitory effect on th whole cholesterol biosynthetic pathway, overview Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5alpha-cholesta-7,24-dien-3beta-ol + NADPH Rattus norvegicus step in the biosynthesis of cholesterol from lanosterol 5alpha-cholest-7-en-3beta-ol + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 male sprague-dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5alpha-cholesta-7,24-dien-3beta-ol + NADPH
-
 Rattus norvegicus 5alpha-cholest-7-en-3beta-ol + NADP+ i.e. lathosterol ?
5alpha-cholesta-7,24-dien-3beta-ol + NADPH step in the biosynthesis of cholesterol from lanosterol Rattus norvegicus 5alpha-cholest-7-en-3beta-ol + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
sterol DELTA24-reductase
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0041
-
 tamoxifen
-
 Rattus norvegicus