Cloned (Comment) | Organism |
---|---|
a Neurospora crassa enzyme-deficient erg-3 mutant strain mat a and a yeast erg-4 mutant strain AP2 cannot be complemented by expression of 6 chimeric enzyme mutants variants constructed from the enzyme encoded by gene TM7SF2 and the Neurospora crassa gene erg-3 encoded enzyme | Homo sapiens |
an enzyme-deficient erg-3 mutant strain mat a and a yeast erg-4 mutant strain AP2 cannot be complemented by expression of 6 chimeric enzyme mutants variants constructed from the enzyme encoded by erg-3 and the human gene TM7SF2 encoding the SR-1 protein | Neurospora crassa |
Protein Variants | Comment | Organism |
---|---|---|
E475Q | site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a | Neurospora crassa |
G225C | site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a | Neurospora crassa |
Y317F | site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a | Neurospora crassa |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | enzyme plays a key role in sterol biosynthesis, sterol content in vivo | ? | - |
? | |
additional information | Neurospora crassa | enzyme plays a key role in sterol biosynthesis, sterol content in vivo | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
gene TM7SF2, enzyme SR-1 | - |
Neurospora crassa | - |
gene erg-3 | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+ = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+ | residues G225, Y317, and E475 are not essential for activity | Neurospora crassa |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
mycelium | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | enzyme plays a key role in sterol biosynthesis, sterol content in vivo | Homo sapiens | ? | - |
? | |
additional information | enzyme plays a key role in sterol biosynthesis, sterol content in vivo | Neurospora crassa | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SR-1 | - |
Homo sapiens |
sterol C-14 reductase | - |
Homo sapiens |
sterol C-14 reductase | - |
Neurospora crassa |