Cloned (Comment) | Organism |
---|---|
- |
Saccharomyces cerevisiae |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of gene disruption mutants, simultaneous disruption of genes FRDS and OSM1 cause a growth defect mutant under anaerobic conditions, while disruption of gene OSM1 alone leads to a slow growth, both due to lack in cellular NAD+, which can be overcome by addition of methylene blue or phenazine methosulfate which oxidized NADH to NAD+ | Saccharomyces cerevisiae |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
soluble | - |
Saccharomyces cerevisiae | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
fumarate + NADH + H+ | Saccharomyces cerevisiae | physiological role in redox balancing during anaerobiosis, both isozymes are required for reoxidation of intracellular NADH | succinate + NAD+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
2 isozymes FRDS1 and FRDS2 encoded by gene FRDS and OSM1, respectively | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
fumarate + NADH + H+ | - |
Saccharomyces cerevisiae | succinate + NAD+ | - |
? | |
fumarate + NADH + H+ | physiological role in redox balancing during anaerobiosis, both isozymes are required for reoxidation of intracellular NADH | Saccharomyces cerevisiae | succinate + NAD+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
FRDS | - |
Saccharomyces cerevisiae |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | - |
Saccharomyces cerevisiae |