Application | Comment | Organism |
---|---|---|
medicine | might serve as target for anti-Leishmania drugs | Leishmania donovani |
medicine | might serve as target for anti-Leishmania drugs | Leishmania major |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Cu2+ | - |
Leishmania donovani | |
Cu2+ | - |
Leishmania major | |
malonate | - |
Leishmania donovani | |
Zn2+ | strong inhibitor | Leishmania donovani | |
Zn2+ | strong inhibitor | Leishmania major |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Leishmania donovani | 16020 | - |
mitochondrion | - |
Leishmania major | 5739 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
65000 | - |
- |
Leishmania donovani |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
fumarate + NADH + H+ | Leishmania donovani | component of respiratory chain | succinate + NAD+ | - |
? | |
fumarate + NADH + H+ | Leishmania major | component of respiratory chain | succinate + NAD+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Leishmania donovani | - |
- |
- |
Leishmania major | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Leishmania donovani |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
amastigote | - |
Leishmania donovani | - |
promastigote | - |
Leishmania donovani | - |
promastigote | - |
Leishmania major | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
2189 | - |
purified enzyme from promastigotes | Leishmania donovani |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
fumarate + NADH + H+ | - |
Leishmania donovani | succinate + NAD+ | - |
? | |
fumarate + NADH + H+ | - |
Leishmania major | succinate + NAD+ | - |
? | |
fumarate + NADH + H+ | component of respiratory chain | Leishmania donovani | succinate + NAD+ | - |
? | |
fumarate + NADH + H+ | component of respiratory chain | Leishmania major | succinate + NAD+ | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | - |
Leishmania donovani | |
NADH | - |
Leishmania major |