Literature summary for 1.3.1.44 extracted from

Mattheus, W.; Masschelein, J.; Gao, L.J.; Herdewijn, P.; Landuyt, B.; Volckaert, G.; Lavigne, R.
The kalimantacin/batumin biosynthesis operon encodes a self-resistance isoform of the FabI bacterial target (2010), Chem. Biol., 17, 1067-1071.

Search for more literature for 1.3.1.44

Cloned(Commentary)

Cloned (Comment)	Organism
wild-type and deletion mutant BatG expression in Pseudomonas fluorescens strain BCCM_ID9359, Escherichia coli, and Staphylococcus aureus, confers resistance against kalimantacin/batumin	Pseudomonas fluorescens

Protein Variants

Protein Variants	Comment	Organism
additional information	generation of a specific in vivo gene inactivation by in-frame deletion of BatG	Pseudomonas fluorescens

Organism

Organism	UniProt	Comment	Textmining
Pseudomonas fluorescens	-	-	-
Pseudomonas fluorescens BCCM_ID9359	-	-	-

Synonyms

Synonyms	Comment	Organism
BatG	-	Pseudomonas fluorescens
More	BatG as a trans-2-enoyl-ACP reductase isozyme, an isozyme of FabI, it contains the conserved NADH-binding motif GxxxGxG and catalytic triad YYK	Pseudomonas fluorescens
trans-2-enoyl-ACP reductase	-	Pseudomonas fluorescens

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Pseudomonas fluorescens
NADH	-	Pseudomonas fluorescens
NADP+	-	Pseudomonas fluorescens
NADPH	-	Pseudomonas fluorescens

General Information

General Information	Comment	Organism
additional information	BatG is an isoform of FabI, conferring full resistance to target bacteria against kalimantacin/batumin and/or triclosan	Pseudomonas fluorescens
physiological function	BatG encodes a functional FabI isozyme which confers full resistance to kalimantacin/batumin and complements FabI. BatG is, similarity to trans-2-enoyl-ACP reductases, involved in the formation of a saturated acyl-ACP by an NAD(P)H-dependent reduction of the trans-2-enoyl-ACP double bond, which is essential for the final step of the elongation cycle of fatty acid biosynthesis. BatG knockout does not influence the kalimantacin/batumin, kal/bat, biosynthesis structurally. Kalimantacin/batumin biosynthesis is BatG-independent, despite BatG localization in the operon among kal/bat tailoring enzymes, overview	Pseudomonas fluorescens

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Release 2023.1 (January 2023)