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Literature summary for 1.3.1.42 extracted from

  • Craig, D.H.; Moody, P.C.; Bruce, N.C.; Scrutton, N.S.
    Reductive and oxidative half-reactions of morphinone reductase from Pseudomonas putida M10: a kinetic and thermodynamic analysis (1998), Biochemistry, 37, 7598-7607.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Pseudomonas putida

Inhibitors

Inhibitors Comment Organism Structure
cortisone
-
Pseudomonas putida
progesterone
-
Pseudomonas putida

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
41100
-
2 * 41100 Pseudomonas putida
82200
-
-
Pseudomonas putida

Organism

Organism UniProt Comment Textmining
Pseudomonas putida
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-cyclohexen-1-one + NADH
-
Pseudomonas putida ? + NAD+
-
?
codeinone + NADH
-
Pseudomonas putida hydrocodone + NAD+
-
?
morphinone + NADH
-
Pseudomonas putida hydromorphone + NAD+
-
?

Subunits

Subunits Comment Organism
homodimer 2 * 41100 Pseudomonas putida

Synonyms

Synonyms Comment Organism
morphine reductase the enzyme is closely related to the isoforms of old yellow enzyme with major differences in the kinetic properties Pseudomonas putida

Cofactor

Cofactor Comment Organism Structure
flavin dependent, contains one molar equivalent of noncovalently bound FMN per enzyme subunit Pseudomonas putida
NADH dependent Pseudomonas putida