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Literature summary for 1.3.1.31 extracted from

  • de Kraker, J.W.; Franssen, M.C.R.; Joerink, M.; de Groot, A.; Bouwmeester, H.J.
    Biosynthesis of costunolide, dihydrocostunolide, and leucodin. Demostration of cytochrome P450-catalyzed formation of the lactone ring present in sesquiterpene lactones of chicory (2002), Plant Physiol., 129, 257-268.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.3.1.31

Activating Compound

Activating Compound Comment Organism Structure
argon 34% activation Cichorium intybus
clotrimazole slight activation Cichorium intybus
CO atmosphere of 80% v/v with 20% v/v O2, 40% activation Cichorium intybus

Inhibitors

Inhibitors Comment Organism Structure
aminobenzotriazole slight inhibition Cichorium intybus
Metyrapone slight inhibition Cichorium intybus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(+)-costunolide + NADPH Cichorium intybus part of the metabolization of (+)-costunolide to leucodin, overview 11(S),13-dihydrocostunolide + NADP+
-
 ?
additional information Cichorium intybus enzyme may be part of the O2-dependent cytochrome P450-enzyme (+)-costunolide synthase, pathway, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Cichorium intybus
-
 chicory
-

Source Tissue

Source Tissue Comment Organism Textmining
root
-
 Cichorium intybus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(+)-costunolide + NADPH
-
 Cichorium intybus 11(S),13-dihydrocostunolide + NADP+
-
 ?
(+)-costunolide + NADPH part of the metabolization of (+)-costunolide to leucodin, overview Cichorium intybus 11(S),13-dihydrocostunolide + NADP+
-
 ?
additional information enzyme may be part of the O2-dependent cytochrome P450-enzyme (+)-costunolide synthase, pathway, overview Cichorium intybus ?
-
 ?

Synonyms

Synonyms Comment Organism
enoate reductase
-
 Cichorium intybus

Cofactor

Cofactor Comment Organism Structure
NADPH dependent on, poor activity with NADH Cichorium intybus