Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.3.1.3 extracted from

  • Charbonneau, A.; The, V.L.
    Genomic organization of a human 5beta-reductase and its pseudogene and substrate selectivity of the expressed enzyme (2001), Biochim. Biophys. Acta, 1517, 228-235.
    View publication on PubMed
Search for more literature for 1.3.1.3

Cloned(Commentary)

Cloned (Comment) Organism
expression in human HEK-293 cells Homo sapiens
pseudogene found Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
17alpha-hydroxyprogesterone + NADPH Homo sapiens
-
 ?
-
 ?
aldosterone + NADPH Homo sapiens low activity ?
-
 ?
corticosterone + NADPH + H+ Homo sapiens low activity ?
-
 ?
cortisol + NADPH Homo sapiens very low activity ?
-
 ?
progesterone + NADPH Homo sapiens
-
 ?
-
 ?
testosterone + NADPH + H+ Homo sapiens
-
 (5beta,17beta)-17-hydroxyandrostan-3-one + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
17alpha-hydroxyprogesterone + NADPH
-
 Homo sapiens ?
-
 ?
4-androstene-3,17-dione + NADPH
-
 Homo sapiens 5beta-androstan-3,17-dione + NADP+
-
 ?
aldosterone + NADPH low activity Homo sapiens ?
-
 ?
corticosterone + NADPH + H+ low activity Homo sapiens ?
-
 ?
cortisol + NADPH very low activity Homo sapiens ?
-
 ?
progesterone + NADPH
-
 Homo sapiens ?
-
 ?
testosterone + NADPH + H+
-
 Homo sapiens (5beta,17beta)-17-hydroxyandrostan-3-one + NADP+
-
 ?