Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
biliverdin IXalpha + NADH + H+ | Homo sapiens | substrate for isoform BVRA | bilirubin IXalpha + NAD+ | - |
r | |
biliverdin IXalpha + NADPH + H+ | Homo sapiens | substrate for isoform BVRA | bilirubin IXalpha + NADP+ | - |
r | |
biliverdin IXbeta + NADH + H+ | Homo sapiens | substrate for isoform BVRB | bilirubin IXbeta + NAD+ | - |
r | |
biliverdin IXbeta + NADPH + H+ | Homo sapiens | substrate for isoform BVRB | bilirubin IXbeta + NADP+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P30043 | - |
- |
Homo sapiens | P53004 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
lung | - |
Homo sapiens | - |
placenta | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
biliverdin IXalpha + NADH + H+ | substrate for isoform BVRA | Homo sapiens | bilirubin IXalpha + NAD+ | - |
r | |
biliverdin IXalpha + NADPH + H+ | substrate for isoform BVRA | Homo sapiens | bilirubin IXalpha + NADP+ | - |
r | |
biliverdin IXbeta + NADH + H+ | substrate for isoform BVRB | Homo sapiens | bilirubin IXbeta + NAD+ | - |
r | |
biliverdin IXbeta + NADPH + H+ | substrate for isoform BVRB | Homo sapiens | bilirubin IXbeta + NADP+ | - |
r |
Synonyms | Comment | Organism |
---|---|---|
BVRA | isoform | Homo sapiens |
BVRB | isoform | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | - |
Homo sapiens | |
NADPH | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | isoform BVRA interacts with components in both the PI3-kinase/Akt and the IRK/IRS/PI3-kinase/MAPK pathyway | Homo sapiens |
physiological function | the enzyme protects against glucose intolerance and diabetes by affecting the pancreatic islet. Isoform BVRA enhances protein kinase CbetaII localization at the cellular membrane and also modulates protein kinase Cdelta and protein kinase Czeta | Homo sapiens |