Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lung | - |
Rattus norvegicus | - |
smooth muscle | pulmonary arterial smooth muscle cell | Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
biliverdin reductase | - |
Rattus norvegicus |
BVR | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | about 56% of the BVR expression in total lung tissue is increased by hypoxia | up |
Rattus norvegicus | up-regulated in levels of protein and mRNA by hypoxia in pulmonary arterial smooth muscle cell | up |
General Information | Comment | Organism |
---|---|---|
malfunction | using BVR siRNA, blocking generation of bilirubin, reverses the effect of hypoxia on enhancing cell survival and apoptotic protein (Bcl-2, procasepase-9, procasepase-3) expression, preventing nuclear shrinkage, DNA fragmentation and mitochondrial depolarization in starved pulmonary arterial smooth muscle cell, which are recovered by exogenous bilirubin. The inhibitory effect of bilirubin on pulmonary arterial smooth muscle cell apoptosis under hypoxic condition is blocked by the inhibitor of ERK1/2 pathway | Rattus norvegicus |