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Literature summary for 1.3.1.24 extracted from

  • Song, S.; Wang, S.; Ma, J.; Yao, L.; Xing, H.; Zhang, L.; Liao, L.; Zhu, D.
    Biliverdin reductase/bilirubin mediates the anti-apoptotic effect of hypoxia in pulmonary arterial smooth muscle cells through ERK1/2 pathway (2013), Exp. Cell Res., 319, 1973-1987.
    View publication on PubMed
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
lung
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 Rattus norvegicus
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smooth muscle pulmonary arterial smooth muscle cell Rattus norvegicus
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Synonyms

Synonyms Comment Organism
biliverdin reductase
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 Rattus norvegicus
BVR
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 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus about 56% of the BVR expression in total lung tissue is increased by hypoxia up
Rattus norvegicus up-regulated in levels of protein and mRNA by hypoxia in pulmonary arterial smooth muscle cell up

General Information

General Information Comment Organism
malfunction using BVR siRNA, blocking generation of bilirubin, reverses the effect of hypoxia on enhancing cell survival and apoptotic protein (Bcl-2, procasepase-9, procasepase-3) expression, preventing nuclear shrinkage, DNA fragmentation and mitochondrial depolarization in starved pulmonary arterial smooth muscle cell, which are recovered by exogenous bilirubin. The inhibitory effect of bilirubin on pulmonary arterial smooth muscle cell apoptosis under hypoxic condition is blocked by the inhibitor of ERK1/2 pathway Rattus norvegicus