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Literature summary for 1.3.1.24 extracted from

  • Jansen, T.; Hortmann, M.; Oelze, M.; Opitz, B.; Steven, S.; Schell, R.; Knorr, M.; Karbach, S.; Schuhmacher, S.; Wenzel, P.; Muenzel, T.; Daiber, A.
    Conversion of biliverdin to bilirubin by biliverdin reductase contributes to endothelial cell protection by heme oxygenase-1-evidence for direct and indirect antioxidant actions of bilirubin (2010), J. Mol. Cell. Cardiol., 49, 186-195.
    View publication on PubMed
Search for more literature for 1.3.1.24

Protein Variants

Protein Variants Comment Organism
additional information since no specific inhibitors for BVR are known, siRNA is used to silence the BVR gene in primary endothelial cells and accordingly suppress its activity Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information since no specific inhibitors for BVR are known, siRNA is used to silence the BVR gene in primary endothelial cells and accordingly suppress its activity Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
bilirubin + NAD+ Homo sapiens
-
 biliverdin + NADH + H+
-
 r
bilirubin + NADP+ Homo sapiens
-
 biliverdin + NADPH + H+
-
 r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
endothelial cell
-
 Homo sapiens
-
neutrophil
-
 Homo sapiens
-
umbilical vein endothelial cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
bilirubin + NAD+
-
 Homo sapiens biliverdin + NADH + H+
-
 r
bilirubin + NADP+
-
 Homo sapiens biliverdin + NADPH + H+
-
 r

Synonyms

Synonyms Comment Organism
BVR
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Homo sapiens
NADH
-
 Homo sapiens
NADP+
-
 Homo sapiens
NADPH
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism BVR is part of the heme oxygenase protection system, overview Homo sapiens
additional information bilirubin is a superior antioxidant in isolated mitochondria and neutrophils as compared to biliverdin, overview. XO-derived superoxide is decreased in a concentration-dependent fashion by bilirubin whereas biliverdin has no inhibitory effect and even significantly increases the signal pointing towards pro-oxidative effects Homo sapiens
physiological function the significant effect of biliverdin on decrease in extracellular oxidative stress in BVR-deficient cells may be related to direct scavenging of extracellular reactive oxygen and nitrogen species by biliverdin Homo sapiens