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Literature summary for 1.3.1.24 extracted from

  • Maines, M.D.; Miralem, T.; Lerner-Marmarosh, N.; Shen, J.; Gibbs, P.E.
    Human biliverdin reductase - a previously unknown activator of protein kinase C beta II (2007), J. Biol. Chem., 282, 8110-8122.
    View publication on PubMed
Search for more literature for 1.3.1.24

Activating Compound

Activating Compound Comment Organism Structure
cobalt protoporphyrin activates Homo sapiens

Application

Application Comment Organism
additional information potential function in propagation of signals relayed through protein kinase C, binds to protein kinase C betaII, increases its phosphorylation, and is a substrate for the kinase, increases PMA-dependent c-fos activation and protein kinase C translocation to the membrane Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
into pcDNA3 and expressed in 293A cells pcDNA3, into pGEX4-T2 and expressed in Escherichia coli Homo sapiens

Protein Variants

Protein Variants Comment Organism
G17A does not effectively bind ATP, hence kinase-dead, is not as effective as the wild-type in potentiating protein kinase C activity Homo sapiens
V11A/V12A/V13A/V14A not only fails to activate protein kinase C but also decreases its activity by 22% Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane role for the enzyme in intracellular traffic of protein kinase C betaII and its membrane translocation Homo sapiens 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
BVR
-
 Homo sapiens