Literature summary for 1.3.1.24 extracted from

Salim, M.; Brown-Kipphut, B.A.; Maines, M.D.
Human biliverdin reductase is autophosphorylated, and phosphorylation is required for bilirubin formation (2001), J. Biol. Chem., 276, 10929-10934.

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Cloned(Commentary)

Cloned (Comment)	Organism
human biliverdin reductase expressed in Escherichia coli	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
potato acid phosphatase	human bilverdin reductase expressed in E. coli	Homo sapiens
Protein phosphatase 2A	human bilverdin reductase expressed in E. coli, okadaic acid attenuates the inhibition	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mn2+	is required for binding of the ATP analogue and for autophosphorylation	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	in Escherichia coli expressed human biliverdin reductase is autophoshorylated and the phosphorylation is required for its activity, the enzyme is a renaturable phosphoprotein and the autophosphorylation is most prominent at pH 8.7, the enzyme is autophosphorylated on serine/threonine residues	Homo sapiens

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Release 2023.1 (January 2023)