Literature summary for 1.3.1.22 extracted from

Murata, K.; Takeshita, F.; Samukawa, K.; Tani, T.; Matsuda, H.
Effects of ginseng rhizome and ginsenoside Ro on testosterone 5alpha-reductase and hair re-growth in testosterone-treated mice (2012), Phytother. Res., 26, 48-53.

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Inhibitors

Inhibitors	Comment	Organism	Structure
ginsenoside Rg3	a unique ginsenoside in red ginseng	Rattus norvegicus
ginsenoside Ro	topical administration of ginsenoside Ro at 0.2 mg/mouse to shaved skin inhibits hair regrowth suppression after shaving in the testosterone-treated C57BL/6 mice	Mus musculus
ginsenoside Ro	predominant ginsenoside in the rhizome of ginseng	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-
Rattus norvegicus	-	-	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.086	-	pH 7.2, 37°C	Rattus norvegicus	ginsenoside Rg3
0.259	-	pH 7.2, 37°C	Rattus norvegicus	ginsenoside Ro

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Release 2023.1 (January 2023)