Literature summary for 1.3.1.22 extracted from

Sharif, A.; Shoae-Hassani, A.; Sharif, S.; Banafshe, H.R.; Mortazavi-Tabatabaei, S.A.; Verdi, J.
5alpha-reductase 1 regulates spinal cord testosterone after morphine administration (2013), Neurol. Sci., 34, 19-23.

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Activating Compound

Activating Compound	Comment	Organism	Structure
morphine	morphine significantly reduces the testosterone concentration after acute and chronic exposure in the spinal cord. In contrast, the 5alpha-reductase 1 expression and of course dihydrotestosterone levels increase tfollowing chronic morphine administration	Rattus norvegicus

Application

Application	Comment	Organism
medicine	morphine significantly reduces the testosterone concentration after acute and chronic exposure in the spinal cord. In contrast, the 5alpha-reductase 1 expression and of course dihydrotestosterone levels increase the following chronic morphine administration	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
spinal cord	-	Rattus norvegicus	-

Expression

Organism	Comment	Expression
Rattus norvegicus	morphine significantly reduces the testosterone concentration after acute and chronic exposure in the spinal cord. In contrast, the 5alpha-reductase 1 expression and of course dihydrotestosterone levels increase the following chronic morphine administration	up

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Release 2023.1 (January 2023)