Cloned (Comment) | Organism |
---|---|
monkey SR type 1 cDNA expression in CHO-cells | Macaca fascicularis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-methyl-4-azasteroids | competitive | Homo sapiens | |
4-methyl-4-azasteroids | competitive | Macaca fascicularis | |
4-methyl-4-azasteroids | competitive | Rattus norvegicus | |
4-methyl-azasteroid | - |
Homo sapiens | |
4-methyl-azasteroid | - |
Macaca fascicularis | |
4-methyl-azasteroid | - |
Rattus norvegicus | |
acrylate episteride | - |
Homo sapiens | |
acrylate episteride | - |
Macaca fascicularis | |
acrylate episteride | - |
Rattus norvegicus | |
finasteride | - |
Homo sapiens | |
finasteride | - |
Macaca fascicularis | |
finasteride | - |
Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0002 | - |
testosterone | isoenzyme 2 | Macaca fascicularis | |
0.0002 | - |
progesterone | isoenzyme 2 | Macaca fascicularis | |
0.0002 | - |
20alpha-hydroxyprogesterone | isoenzyme 1 | Homo sapiens | |
0.0003 | - |
progesterone | isoenzyme 2 | Homo sapiens | |
0.0003 | - |
progesterone | isoenzyme 1 | Homo sapiens | |
0.0003 | - |
progesterone | isoenzyme 1 | Macaca fascicularis | |
0.0004 | - |
androstenedione | isoenzyme 2 | Macaca fascicularis | |
0.0004 | - |
20alpha-hydroxyprogesterone | isoenzyme 2 | Homo sapiens | |
0.0005 | - |
20alpha-hydroxyprogesterone | isoenzyme 1 | Macaca fascicularis | |
0.0006 | - |
androstenedione | isoenzyme 1 | Macaca fascicularis | |
0.0007 | - |
testosterone | isoenzyme 2 | Homo sapiens | |
0.0008 | - |
androstenedione | isoenzyme 2 | Homo sapiens | |
0.001 | - |
androstenedione | isoenzyme 1 | Homo sapiens | |
0.002 | - |
corticosterone | isoenzyme 2 | Macaca fascicularis | |
0.002 | - |
testosterone | isoenzyme 1 | Macaca fascicularis | |
0.0035 | - |
testosterone | isoenzyme 1 | Homo sapiens | |
0.004 | - |
corticosterone | isoenzyme 2 | Homo sapiens | |
0.008 | - |
corticosterone | isoenzyme 1 | Macaca fascicularis | |
0.018 | - |
corticosterone | isoenzyme 1 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Macaca fascicularis | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
prostate gland | - |
Homo sapiens | - |
prostate gland | - |
Rattus norvegicus | - |
prostate gland | - |
Macaca fascicularis | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
20-alpha-hydroxypregn-4-ene-3one + NADPH | - |
Homo sapiens | 20-alpha-hydroxy-5alpha-pregnan-3-one + NADP+ | - |
? | |
20-alpha-hydroxypregn-4-ene-3one + NADPH | - |
Macaca fascicularis | 20-alpha-hydroxy-5alpha-pregnan-3-one + NADP+ | - |
? | |
androstenedione + NADPH + H+ | - |
Homo sapiens | 5alpha-androstan-3,17-dione + NADP+ | - |
? | |
androstenedione + NADPH + H+ | - |
Rattus norvegicus | 5alpha-androstan-3,17-dione + NADP+ | - |
? | |
androstenedione + NADPH + H+ | - |
Macaca fascicularis | 5alpha-androstan-3,17-dione + NADP+ | - |
? | |
corticosterone + NADPH + H+ | - |
Homo sapiens | 5alpha-dihydrocorticosterone + NADP+ | - |
r | |
corticosterone + NADPH + H+ | - |
Macaca fascicularis | 5alpha-dihydrocorticosterone + NADP+ | - |
r | |
deoxycorticosterone + NADPH | - |
Homo sapiens | 21-hydroxy-5alpha-pregnan-3,20-dione | - |
? | |
deoxycorticosterone + NADPH | - |
Rattus norvegicus | 21-hydroxy-5alpha-pregnan-3,20-dione | - |
? | |
deoxycorticosterone + NADPH | - |
Macaca fascicularis | 21-hydroxy-5alpha-pregnan-3,20-dione | - |
? | |
progesterone + NADPH + H+ | - |
Homo sapiens | 5alpha-pregnan-3,20-dione + NADP+ | - |
? | |
progesterone + NADPH + H+ | - |
Rattus norvegicus | 5alpha-pregnan-3,20-dione + NADP+ | - |
? | |
progesterone + NADPH + H+ | - |
Macaca fascicularis | 5alpha-pregnan-3,20-dione + NADP+ | - |
? | |
testosterone + NADPH + H+ | - |
Homo sapiens | 17beta-hydroxy-5alpha-androstan-3-one + NADP+ | - |
? | |
testosterone + NADPH + H+ | - |
Rattus norvegicus | 17beta-hydroxy-5alpha-androstan-3-one + NADP+ | - |
? | |
testosterone + NADPH + H+ | - |
Macaca fascicularis | 17beta-hydroxy-5alpha-androstan-3-one + NADP+ | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5 | - |
recombinant monkey 5alpha-reductase isozyme 2 | Macaca fascicularis |
5 | - |
recombinant human 5alpha-reductase isozyme 2 | Homo sapiens |
7.5 | - |
recombinant human 5alpha-reductase isozyme 1 | Homo sapiens |
8 | - |
recombinant monkey 5alpha-reductase isozyme 1 | Macaca fascicularis |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
4.5 | 9.5 | recombinant human 5alpha-reductase isozyme 2 | Homo sapiens |
4.5 | 7.5 | recombinant monkey 5alpha-reductase isozyme 2 | Macaca fascicularis |
4.5 | 9 | recombinant human 5alpha-reductase isozyme 1 | Homo sapiens |
5.5 | 9 | recombinant monkey 5alpha-reductase isozyme 1 | Macaca fascicularis |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000003 | - |
acylate episteride | iosenzyme 2 | Homo sapiens | |
0.0000005 | - |
acylate episteride | iosenzyme 2 | Macaca fascicularis | |
0.000001 | - |
finasteride | iosenzyme 2 | Homo sapiens | |
0.000002 | - |
4-methyl-azasteroid | iosenzyme 2 | Macaca fascicularis | |
0.000003 | - |
4-methyl-azasteroid | iosenzyme 1 | Homo sapiens | |
0.000003 | - |
4-methyl-azasteroid | iosenzyme 1 | Macaca fascicularis | |
0.000003 | - |
4-methyl-azasteroid | iosenzyme 2 | Rattus norvegicus | |
0.000004 | - |
finasteride | iosenzyme 2 | Rattus norvegicus | |
0.000004 | - |
4-methyl-azasteroid | iosenzyme 2 | Homo sapiens | |
0.000004 | - |
acylate episteride | iosenzyme 2 | Rattus norvegicus | |
0.000005 | - |
finasteride | iosenzyme 2 | Macaca fascicularis | |
0.000006 | - |
finasteride | iosenzyme 1 | Rattus norvegicus | |
0.000008 | - |
4-methyl-azasteroid | iosenzyme 1 | Rattus norvegicus | |
0.00002 | - |
acylate episteride | iosenzyme 1 | Rattus norvegicus | |
0.00022 | - |
finasteride | iosenzyme 1 | Macaca fascicularis | |
0.0005 | - |
acylate episteride | iosenzyme 1 | Macaca fascicularis | |
0.001 | - |
finasteride | iosenzyme 1 | Homo sapiens | |
0.0041 | - |
acylate episteride | iosenzyme 1 | Homo sapiens |