Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.3.1.22 extracted from

  • Tian, G.; Mook, R.; Moss, M.L.; Frye, S.V.
    Mechanism of time-dependent inhibition of 5alpha-reductases by delta 1-4-azasteroids: Toward perfection of rates of time-dependent inhibition by using ligand-binding energies (1995), Biochemistry, 34, 13453-13459.
    View publication on PubMed
Search for more literature for 1.3.1.22

Inhibitors

Inhibitors Comment Organism Structure
alpha-4-azasteroids substitution of finasteride N-group by 6-azasteroids increased the rate of inhibition of type-1 5-alpha-reductases Homo sapiens
finasteride 17-beta-N-tert-butylcarbonyl-4-aza-5alpha-androstan-1-en-3-one is a time-dependent, apparently irreversible inhibitor of 5alpha-reductases, but does not fully inhibit the activity of 5alpha-reductase in vivo Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00069
-
 progesterone
-
 Homo sapiens
0.0063
-
 testosterone
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
progesterone + NADPH + H+
-
 Homo sapiens 5alpha-pregnan-3,20-dione + NADP+
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00036
-
 finasteride
-
 Homo sapiens