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Literature summary for 1.3.1.22 extracted from
- Testosterone 5alpha-reductase in spinal cord of Xenopus laevis (1982), J. Neurochem., 38, 657-661.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.002 | - |
testosterone | - |
Xenopus laevis |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Xenopus laevis | - |
South African clawed frog | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| spinal cord | - |
Xenopus laevis | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cholest-4-en-3-one + NADPH | - |
Xenopus laevis | 5-alpha-cholestan-3-one + NADP+ | - |
? | |
| testosterone + NADPH + H+ | - |
Xenopus laevis | 17beta-hydroxy-5alpha-androstan-3-one + NADP+ | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 27 | - |
- |
Xenopus laevis |
Temperature Range [°C]
| Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 21 | 37 | 21°C: about 50% of activity maximum, 37°C: about 70% of activity maximum | Xenopus laevis |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
- |
Xenopus laevis |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | 8.6 | half maximal activity at pH 6.5 and 8.6 | Xenopus laevis |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Xenopus laevis | |
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Release 2023.1 (January 2023)
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