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Literature summary for 1.3.1.22 extracted from
- Biochemical characterization of the NADPH: 4-ene-3-ketosteroid 5alpha-oxidoreductase in rat ovarian suspension cultures (1979), J. Steroid Biochem., 10, 325-333.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4-Ene-3-keto-steroids | 17beta-estradiol in high concentrations functions as an uncompetitive inhibitor | Rattus norvegicus |  |
| estradiol-17beta | high concentration | Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00057 | - |
17-epitestosterone | in homogenates | Rattus norvegicus | |
| 0.00078 | - |
17-epitestosterone | in living cells | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| ovary | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 17-epitestosterone + NADPH | - |
Rattus norvegicus | ? | - |
? | |
| cholest-4-en-3-one + NADPH | - |
Rattus norvegicus | 5-alpha-cholestan-3-one + NADP+ | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
- |
Rattus norvegicus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 4.5 | 9 | pH .5: about 30% of activity maximum, pH 9.0: about 20% of activity maximum | Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Rattus norvegicus | |
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