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Literature summary for 1.3.1.22 extracted from
- Partial characterization of the microsomal and solubilized hypothalamic progesterone 5alpha-reductase (1984), J. Steroid Biochem., 21, 305-314.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| iodoacetamide | stimulatory on solubilized enzyme from microsomes | Rattus norvegicus |  |
| N-ethylmaleimide | stimulatory on solubilized enzyme from microsomes | Rattus norvegicus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4-Aza-4-methyl-5alpha-pregnane-3,20-dione | - |
Rattus norvegicus | |
| Cu2+ | - |
Rattus norvegicus | |
| flavins | and flavin analogs, high concentration | Rattus norvegicus | |
| p-chloromercuribenzoate | complete inhibition | Rattus norvegicus | |
| Zn2+ | - |
Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.000113 | - |
progesterone | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| EDTA | - |
Rattus norvegicus | |
| K+ | stimulate | Rattus norvegicus | |
| Li+ | stimulate | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| progesterone + NADPH + H+ | Rattus norvegicus | riboflavin-deficient diet decreases the enzyme activity, after 5 weeks no activity is remaining | 5alpha-pregnan-3-20-dione + NADP+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| hypothalamus | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| progesterone + NADPH + H+ | - |
Rattus norvegicus | 5alpha-pregnan-3-20-dione + NADP+ | - |
? | |
| progesterone + NADPH + H+ | riboflavin-deficient diet decreases the enzyme activity, after 5 weeks no activity is remaining | Rattus norvegicus | 5alpha-pregnan-3-20-dione + NADP+ | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Rattus norvegicus | |
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