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Literature summary for 1.3.1.21 extracted from

  • Xiao, J.; Li, W.; Zheng, X.; Qi, L.; Wang, H.; Zhang, C.; Wan, X.; Zheng, Y.; Zhong, R.; Zhou, X.; Lu, Y.; Li, Z.; Qiu, Y.; Liu, C.; Zhang, F.; Zhang, Y.; Xu, X.; Yang, Z.; Chen, H.; Zhai, Q.; Wei, B.; Wang, H.
    Targeting 7-dehydrocholesterol reductase integrates cholesterol metabolism and IRF3 activation to eliminate infection (2020), Immunity, 52, 109-122.e6 .
    View publication on PubMed
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Application

Application Comment Organism
medicine upon DNA and RNA viral infection, macrophages reduce 7-dehydrocholesterol reductase (DHCR7) expression. DHCR7 deficiency or treatment with 7-dehydrocholesterol (7-DHC) can specifically promote phosphorylation of IRF3 and enhance type I interferon production in macrophages. Viral infection or 7-DHC treatment enhances AKT3 expression and activation. Deletion of DHCR7 and the DHCR7 inhibitors including AY9944 and the chemotherapy drug tamoxifen promote clearance of Zika virus and multiple viruses in vitro or in vivo Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9UBM7
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-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage
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 Homo sapiens
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General Information

General Information Comment Organism
physiological function upon DNA and RNA viral infection, macrophages reduce 7-dehydrocholesterol reductase (DHCR7) expression. DHCR7 deficiency or treatment with 7-dehydrocholesterol (7-DHC) can specifically promote phosphorylation of IRF3 and enhance type I interferon production in macrophages. Viral infection or 7-DHC treatment enhances AKT3 expression and activation. Deletion of DHCR7 and the DHCR7 inhibitors including AY9944 and the chemotherapy drug tamoxifen promote clearance of Zika virus and multiple viruses in vitro or in vivo Homo sapiens