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Literature summary for 1.3.1.21 extracted from

  • Prabhu, A.V.; Luu, W.; Li, D.; Sharpe, L.J.; Brown, A.J.
    DHCR7: A vital enzyme switch between cholesterol and vitamin D production (2016), Prog. Lipid Res., 64, 138-151.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
Homo sapiens 5783
-
membrane
-
Homo sapiens 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
55000
-
x * 55000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cholesterol + NADP+ Homo sapiens
-
cholesta-5,7-dien-3beta-ol + NADPH + H+
-
?
desmosterol + NADP+ Homo sapiens
-
7-dehydrodesmosterol + NADPH + H+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholesterol + NADP+
-
Homo sapiens cholesta-5,7-dien-3beta-ol + NADPH + H+
-
?
desmosterol + NADP+
-
Homo sapiens 7-dehydrodesmosterol + NADPH + H+
-
?

Subunits

Subunits Comment Organism
? x * 55000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
Dhcr7
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Homo sapiens

General Information

General Information Comment Organism
malfunction mutations in the enzyme gene lead to the developmental disease Smith-Lemli-Opitz syndrome which can also result in fetal mortality Homo sapiens
metabolism the enzyme exerts complex biological effects, involved in both cholesterol and vitamin D production Homo sapiens