Protein Variants | Comment | Organism |
---|---|---|
E288K | the mutation is associated with Lemli-Opitz syndrome | Homo sapiens |
E448K | the mutation is associated with Lemli-Opitz syndrome | Homo sapiens |
F302L | the mutation is associated with Lemli-Opitz syndrome | Homo sapiens |
G147D | the mutation is associated with Lemli-Opitz syndrome | Homo sapiens |
G303R | the mutation is associated with Lemli-Opitz syndrome | Homo sapiens |
G410S | the mutation is associated with Lemli-Opitz syndrome | Homo sapiens |
H119L | the mutation is associated with Lemli-Opitz syndrome | Homo sapiens |
H301Q | the mutation is associated with Lemli-Opitz syndrome | Homo sapiens |
H405Y | the mutation is associated with Lemli-Opitz syndrome | Homo sapiens |
L157P | the mutation is associated with Lemli-Opitz syndrome | Homo sapiens |
L99P | the mutation is associated with Lemli-Opitz syndrome | Homo sapiens |
P51S | the mutation is associated with Lemli-Opitz syndrome | Homo sapiens |
Q98X | the mutation is associated with Lemli-Opitz syndrome | Homo sapiens |
R242C | the mutation is associated with Lemli-Opitz syndrome | Homo sapiens |
R352Q | the mutation is associated with Lemli-Opitz syndrome | Homo sapiens |
R352W | the mutation is associated with Lemli-Opitz syndrome | Homo sapiens |
R363C | the mutation is associated with Lemli-Opitz syndrome | Homo sapiens |
R404C | the mutation is associated with Lemli-Opitz syndrome | Homo sapiens |
S113C | the mutation is associated with Lemli-Opitz syndrome | Homo sapiens |
S169L | the mutation is associated with Lemli-Opitz syndrome | Homo sapiens |
T154R | the mutation is associated with Lemli-Opitz syndrome | Homo sapiens |
T93M | the mutation is associated with Lemli-Opitz syndrome | Homo sapiens |
V326L | the mutation is associated with Lemli-Opitz syndrome | Homo sapiens |
V326R | the mutation is associated with Lemli-Opitz syndrome | Homo sapiens |
V330M | the mutation is associated with Lemli-Opitz syndrome | Homo sapiens |
W151X | the mutation is associated with Lemli-Opitz syndrome | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(+)-pachysamine B | - |
Homo sapiens | |
3'-methoxy-4'-hydroxyclomiphene | - |
Homo sapiens | |
afimoxifene | - |
Homo sapiens | |
Chloropromazine | - |
Homo sapiens | |
clozapine | - |
Homo sapiens | |
cyclopamine | - |
Homo sapiens | |
doxorubicin | - |
Homo sapiens | |
epipachysamine D | - |
Homo sapiens | |
haloperidol | - |
Homo sapiens | |
LY-117018 | - |
Homo sapiens | |
monomethylarsonous acid | - |
Homo sapiens | |
N-nitrosodimethylamine | - |
Homo sapiens | |
nafoxidine | - |
Homo sapiens | |
ochratoxin A | - |
Homo sapiens | |
potassium dichromate | - |
Homo sapiens | |
proadifen | - |
Homo sapiens | |
progesterone | - |
Homo sapiens | |
rel-ormeloxifene | - |
Homo sapiens | |
simvastatin | - |
Homo sapiens | |
tamoxifen | - |
Homo sapiens | |
tesmilifene | - |
Homo sapiens | |
trioxifene | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesterol + NADP+ | Homo sapiens | - |
cholesta-5,7-dien-3beta-ol + NADPH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesterol + NADP+ | - |
Homo sapiens | cholesta-5,7-dien-3beta-ol + NADPH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Dhcr7 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000012 | - |
pH and temperature not specified in the publication | Homo sapiens | tamoxifen | |
0.000022 | - |
pH and temperature not specified in the publication | Homo sapiens | 3'-methoxy-4'-hydroxyclomiphene | |
0.00015 | - |
pH and temperature not specified in the publication | Homo sapiens | doxorubicin | |
0.0006 | - |
pH and temperature not specified in the publication | Homo sapiens | (+)-pachysamine B | |
0.02 | - |
pH and temperature not specified in the publication | Homo sapiens | epipachysamine D |
General Information | Comment | Organism |
---|---|---|
malfunction | the Lemli-Opitz syndrome results from mutations in the 7-dehydrocholesterol reductase gene | Homo sapiens |