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Literature summary for 1.3.1.21 extracted from
- Phosphorylation regulates activity of 7-dehydrocholesterol reductase (DHCR7), a terminal enzyme of cholesterol synthesis (2017), J. Steroid Biochem. Mol. Biol., 165, 363-368.
General Stability
| General Stability | Organism |
|---|---|
| inhibition of AMP-activated protein kinase or protein kinase A abolishes enzyme activity | Mesocricetus auratus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cholesterol + NADP+ | Mesocricetus auratus | - |
cholesta-5,7-dien-3beta-ol + NADPH + H+ | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mesocricetus auratus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | - |
Mesocricetus auratus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| CHO-7 cell | - |
Mesocricetus auratus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cholesterol + NADP+ | - |
Mesocricetus auratus | cholesta-5,7-dien-3beta-ol + NADPH + H+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Dhcr7 | - |
Mesocricetus auratus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADP+ | - |
Mesocricetus auratus | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the terminal enzyme of cholesterol synthesis is essential for embryonic development | Mesocricetus auratus |
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Release 2023.1 (January 2023)
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