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Literature summary for 1.3.1.21 extracted from

  • Yoshiyama-Yanagawa, T.; Enya, S.; Shimada-Niwa, Y.; Yaguchi, S.; Haramoto, Y.; Matsuya, T.; Shiomi, K.; Sasakura, Y.; Takahashi, S.; Asashima, M.; Kataoka, H.; Niwa, R.
    The conserved Rieske oxygenase DAF-36/Neverland is a novel cholesterol-metabolizing enzyme (2011), J. Biol. Chem., 286, 25756-25762.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.3.1.21

Cloned(Commentary)

Cloned (Comment) Organism
expression in S2 cell Caenorhabditis elegans
expression in S2 cell Bombyx mori

Protein Variants

Protein Variants Comment Organism
C122A mutation within Rieske [2Fe-2S]-motif, complete loss of activity Caenorhabditis elegans
D234A mutation within non-heme Fe(II) binding motif, complete loss of activity Caenorhabditis elegans
H190A mutation within Rieske [2Fe-2S]-motif, complete loss of activity Bombyx mori
H282A mutation within non-heme Fe(II) binding motif, complete loss of activity Bombyx mori

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Caenorhabditis elegans
-
-
microsome
-
 Bombyx mori
-
-

Organism

Organism UniProt Comment Textmining
Bombyx mori Q1JUZ2
-
-
Caenorhabditis elegans Q17938
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholesterol + O2 + NAD(P)H + H+
-
 Caenorhabditis elegans cholesta-5,7-dien-3beta-ol + NAD(P)+ + 2 H2O
-
 ?
cholesterol + O2 + NAD(P)H + H+
-
 Bombyx mori cholesta-5,7-dien-3beta-ol + NAD(P)+ + 2 H2O
-
 ?

Synonyms

Synonyms Comment Organism
DAF-36
-
 Caenorhabditis elegans
Neverland
-
 Bombyx mori
Nvd
-
 Bombyx mori

General Information

General Information Comment Organism
physiological function wild-type Bombyx mori enzyme rescues the lethality of Drosophila melanogaster animals treated with RNAi against the nvd gene, whereas Bombyx mori mutants H190A and H282A do not Bombyx mori