Literature summary for 1.3.1.21 extracted from

Wollam, J.; Magomedova, L.; Magner, D.B.; Shen, Y.; Rottiers, V.; Motola, D.L.; Mangelsdorf, D.J.; Cummins, C.L.; Antebi, A.
The Rieske oxygenase DAF-36 functions as a cholesterol 7-desaturase in steroidogenic pathways governing longevity (2011), Aging Cell, 10, 879-884.

Search for more literature for 1.3.1.21

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Sf9 cell	Caenorhabditis elegans

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
microsome	-	Caenorhabditis elegans	-	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
cholesterol + O2 + NAD(P)H + H+	Caenorhabditis elegans	first committed step in biosynthesis of Caenorhabditis elegans bile acid-like steroids called dafachronic acids	cholesta-5,7-dien-3beta-ol + NAD(P)+ + 2 H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Caenorhabditis elegans	Q17938	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
cholesterol + O2 + NAD(P)H + H+	first committed step in biosynthesis of Caenorhabditis elegans bile acid-like steroids called dafachronic acids	Caenorhabditis elegans	cholesta-5,7-dien-3beta-ol + NAD(P)+ + 2 H2O	-	?

Synonyms

Synonyms	Comment	Organism
DAF-36	-	Caenorhabditis elegans

General Information

General Information	Comment	Organism
physiological function	by controlling dafachronic acid production, enzyme DAF-36 regulates activities of nuclear receptor DAF-12 for reproductive development and longevity. Mutants deficient for the enzyme lack 7-dehydrocholesterol, revealing a 6.5fold decrease relative to wild-type, and accumulate the putative precursor, cholesterol, by 3fold. The ligand of nuclear receptor DAF-12, DELTA7-dafachronic acid, is also undetectable in the mutants, while DELTA4-dafachronic acid is below the detection limit in both wild-type and mutant	Caenorhabditis elegans

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Release 2023.1 (January 2023)