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Literature summary for 1.3.1.21 extracted from

  • Rahier, A.; Taton, M.
    Sterol biosynthesis: Strong inhibition of maize DELTA5,7-sterol DELTA7-reductase by novel 6-aza-B-homosteroids and other analogs of a presumptive carbocationic intermediate of the reduction reaction (1996), Biochemistry, 35, 7069-7076.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
6,7-diaza-5alpha-cholest-8(14)-en-3beta-ol
-
Zea mays
6,7-diaza-5beta-cholest-8(14)-en-3beta-ol
-
Zea mays
6-aza-B-homo-5alpha-cholest-7-en-3beta-ol
-
Zea mays
6-aza-B-homo-5alpha-cholest-8-en-3beta-ol
-
Zea mays
8beta-cyano-6,7-diaza-5alpha-cholest-5-en-3beta-ol
-
Zea mays
cholest-5,7-dien-3beta-ol
-
Zea mays

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Zea mays
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cholesta-5,7-dien-3-beta-ol + NADPH Zea mays
-
cholesterol + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Zea mays
-
maize
-

Reaction

Reaction Comment Organism Reaction ID
cholesterol + NADP+ = cholesta-5,7-dien-3beta-ol + NADPH + H+ carbocationic intermediate, mechanism Zea mays

Source Tissue

Source Tissue Comment Organism Textmining
seedling
-
Zea mays
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholesta-5,7-dien-3-beta-ol + NADPH
-
Zea mays cholesterol + NADP+
-
?
cholesta-5,7-dien-3beta-ol + NADPH
-
Zea mays cholesterol + NADP+
-
?

Synonyms

Synonyms Comment Organism
DELTA5,7-sterol DELTA7-reductase
-
Zea mays

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Zea mays

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Zea mays

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00005
-
6,7-diaza-5alpha-cholest-8(14)-en-3beta-ol
-
Zea mays
0.00007
-
6-aza-B-homo-5alpha-cholest-7-en-3beta-ol
-
Zea mays
0.5
-
cholest-5,7-dien-3beta-ol
-
Zea mays