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Literature summary for 1.3.1.21 extracted from

  • Dempsey, M.E.; Seaton, J.D.; Schroepfer, G.J.; Trockman, R.W.
    The intermediary role of DELTA5,7-cholestadien-3beta-ol in cholesterol biosynthesis (1964), J. Biol. Chem., 239, 1381-1387.
    View publication on PubMed
Search for more literature for 1.3.1.21

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome probably additional soluble cofactor required Rattus norvegicus
-
-
additional information microsome fraction plus soluble fraction Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cholesta-5,7-dien-3-beta-ol + NADPH Rattus norvegicus cholesterol biosynthesis cholesterol + NADP+
-
 ?
cholesta-5,7-dien-3-beta-ol + NADPH Rattus norvegicus reversibility of the reaction in vivo could not be proven cholesterol + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholesta-5,7-dien-3-beta-ol + NADPH cholesterol biosynthesis Rattus norvegicus cholesterol + NADP+
-
 ?
cholesta-5,7-dien-3-beta-ol + NADPH reversibility of the reaction in vivo could not be proven Rattus norvegicus cholesterol + NADP+
-
 ?
cholesta-5,7-dien-3beta-ol + NADPH
-
 Rattus norvegicus cholesterol + NADP+
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.3
-
 assay at, phosphate buffer 0.1 M Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Rattus norvegicus