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Literature summary for 1.3.1.20 extracted from

  • Cheng, Y.W.; Tsai, H.J.; Wu, J.Y.; Hsu, Y.F.; Chen, C.Y.; Hao, N.J.; Lee, H.
    A possible role for dihydrodiol dehydrogenase in the formation of benzo[a]pyrene-DNA adducts in lung cancer cells and tumor tissues (2006), Environ. Mol. Mutagen., 48, 14-21.
    View publication on PubMed

Application

Application Comment Organism
medicine reduction of enzyme expression in lung tumors may contribute to an increase in DNA adduct levels and may partly be responsible for the higher susceptibility of female lung cancer patients to DNA damage. Detection of DNA adducts correlates with CYP1A1-positive tumors, but not with isoform DDH1-positive tumors Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information knock down of enzyme isoform DHH1 expression by siRNA in CL-3 cells results in 1.4- to 2.2fold increase in DNA-benzo[a]pyrene adducts Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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role of enzyme in formation of benzo[a]pyrene adducts
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Source Tissue

Source Tissue Comment Organism Textmining
CL-3 cell lung cancer cell line, high expression of enzyme isoform DDH1 and enzyme CYP1A1, and high level of DNA-benzo[a]pyrene adducts Homo sapiens
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CL1-1 cell lung cancer cell line, high expression of enzyme isoform DDH1 and enzyme CYP1A1, and high level of DNA-benzo[a]pyrene adducts Homo sapiens
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lung lung cancer cell lines Homo sapiens
-