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Literature summary for 1.3.1.20 extracted from

  • Seike, K.; Murata, M.; Hirakawa, K.; Deyashiki, Y.; Kawanishi, S.
    Oxidative DNA damage induced by benz[a]anthracene dihydrodiols in the presence of dihydrodiol dehydrogenase (2004), Chem. Res. Toxicol., 17, 1445-1451.
    View publication on PubMed

Application

Application Comment Organism
medicine enzyme may play an important role in benz[a]pyrene carcinogenesis via oxidative DNA damage Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus enzyme catalyzes formation of benz[a]anthracene-1,2-dihydrodiol which causes Cu[II]-mediated DNA damage including 8-oxo-7,8-dihydro-2’-deoxyguanosine formation in the presence of NAD+ ?
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Organism

Organism UniProt Comment Textmining
Mus musculus
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recombinant protein expressed in Escherichia coli
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme catalyzes formation of benz[a]anthracene-1,2-dihydrodiol which causes Cu[II]-mediated DNA damage including 8-oxo-7,8-dihydro-2’-deoxyguanosine formation in the presence of NAD+ Mus musculus ?
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?