Cloned (Comment) | Organism |
---|---|
DD4, expression in Escherichia coli JM109 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-Indanone | recombinant DD4 | Homo sapiens | |
17beta-estradiol | DD4, recombinant enzyme | Homo sapiens | |
3',3'',5',5''-tetrabromophenolphthalein | recombinant DD4 | Homo sapiens | |
Betamethasone | DD4, recombinant enzyme | Homo sapiens | |
Bromophenol blue | recombinant DD4 | Homo sapiens | |
dexamethasone | DD4, recombinant enzyme | Homo sapiens | |
Flufenamic acid | DD4, recombinant enzyme | Homo sapiens | |
Hexestrol | DD4, recombinant enzyme | Homo sapiens | |
indomethacin | recombinant DD4 | Homo sapiens | |
Phenol red | recombinant DD4 | Homo sapiens | |
Phenolphthalein | DD4, recombinant enzyme, inhibition mechanism | Homo sapiens | |
phenolphthalein phosphate | recombinant DD4 | Homo sapiens | |
Thymolphthalein | recombinant DD4 | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
35000 | - |
recombinant DD4, gel filtration | Homo sapiens |
36000 | - |
DD4, native PAGE | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
DD4 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
2.23 | - |
recombinant DD4, substrate (S)-indan-1-ol | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(R)-indan-1-ol + NADP+ | - |
Homo sapiens | ? | - |
? | |
(S)-indan-1-ol + NADP+ | - |
Homo sapiens | ? | - |
? | |
5alpha-dihydrotestosterone + NADPH + H+ | - |
Homo sapiens | 5alpha-androstan-3alpha,17beta-diol + NADP+ | - |
? | |
5beta-androstan-3,17-dione + NADPH | - |
Homo sapiens | 5beta-androstan-3alpha-ol-17-one + NADP+ | - |
? | |
5beta-androstan-3alpha,17beta-diol + NADP+ | - |
Homo sapiens | 5beta-androstan-3,17-dione + NADPH | - |
? | |
5beta-dihydrocortisone + NADPH | - |
Homo sapiens | ? | - |
? | |
5beta-pregnan-3,20-diol + NADP+ | - |
Homo sapiens | 5beta-pregnan-20-ol-3-one + NADPH | - |
? | |
5beta-pregnan-3,20-dione + NADPH | - |
Homo sapiens | 3alpha-hydroxy-5beta-pregnan-20-one + NADP+ | - |
? | |
7alpha-hydroxy-5beta-cholestan-3-one + NADPH | - |
Homo sapiens | ? | - |
? | |
androsterone + NADPH | - |
Homo sapiens | ? | - |
? | |
cholic acid + NADP+ | - |
Homo sapiens | ? | - |
? | |
lithocholic acid + NADP+ | - |
Homo sapiens | ? | - |
? | |
pyridine-3-aldehyde + NADPH | - |
Homo sapiens | ? | - |
? | |
trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+ | - |
Homo sapiens | catechol + NAD(P)H | - |
? | |
trans-naphthalene dihydrodiol + NAD(P)+ | - |
Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | 1* 35000, recombinant DD4, 1 * 36000, native DD4, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
DD | - |
Homo sapiens |
dihydrodiol dehydrogenase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00008 | - |
Phenolphthalein | recombinant DD4 | Homo sapiens | |
0.15 | - |
1-Indanone | recombinant DD4 | Homo sapiens |