Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Dehydrolithocholic acid | DD2 | Homo sapiens | |
Flufenamic acid | DD2 | Homo sapiens | |
indomethacin | DD2 | Homo sapiens | |
lithocholic acid | DD2 | Homo sapiens | |
additional information | DD2, product inhibition and inhibition mechanism of bile acids and anti-inflammatory drugs | Homo sapiens | |
naproxen | DD2 | Homo sapiens | |
ursodeoxylithocholic acid | DD2 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | involved in the metabolism of steroid hormones and polycyclic aromatic hydrocarbons, and also in the reduction of ketone-containing drugs | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
DD2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-indan-1-ol + NADP+ | - |
Homo sapiens | ? | - |
? | |
additional information | involved in the metabolism of steroid hormones and polycyclic aromatic hydrocarbons, and also in the reduction of ketone-containing drugs | Homo sapiens | ? | - |
? | |
trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+ | - |
Homo sapiens | catechol + NAD(P)H | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DD | - |
Homo sapiens |
dihydrodiol dehydrogenase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Homo sapiens | |
NADPH | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00004 | - |
lithocholic acid | DD2 | Homo sapiens | |
0.00006 | - |
ursodeoxylithocholic acid | DD2 | Homo sapiens | |
0.00009 | - |
Dehydrolithocholic acid | DD2 | Homo sapiens | |
0.0006 | - |
Flufenamic acid | DD2 | Homo sapiens | |
0.0011 | - |
naproxen | DD2 | Homo sapiens | |
0.076 | - |
indomethacin | DD2 | Homo sapiens |