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Literature summary for 1.3.1.20 extracted from

  • Miyabe, Y.; Amano, T.; Deyashiki, Y.; Hara, A.; Tsukada, F.
    Kinetic studies of the inhibition of a human liver 3alpha-hydroxysteroid/dihydrodiol dehydrogenase isozyme by bile acids and anti-inflammatory drugs (1995), Biol. Pharm. Bull., 18, 9-12.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Dehydrolithocholic acid DD2 Homo sapiens
Flufenamic acid DD2 Homo sapiens
indomethacin DD2 Homo sapiens
lithocholic acid DD2 Homo sapiens
additional information DD2, product inhibition and inhibition mechanism of bile acids and anti-inflammatory drugs Homo sapiens
naproxen DD2 Homo sapiens
ursodeoxylithocholic acid DD2 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens involved in the metabolism of steroid hormones and polycyclic aromatic hydrocarbons, and also in the reduction of ketone-containing drugs ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
DD2
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-indan-1-ol + NADP+
-
Homo sapiens ?
-
?
additional information involved in the metabolism of steroid hormones and polycyclic aromatic hydrocarbons, and also in the reduction of ketone-containing drugs Homo sapiens ?
-
?
trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+
-
Homo sapiens catechol + NAD(P)H
-
?

Synonyms

Synonyms Comment Organism
DD
-
Homo sapiens
dihydrodiol dehydrogenase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Homo sapiens
NADPH
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00004
-
lithocholic acid DD2 Homo sapiens
0.00006
-
ursodeoxylithocholic acid DD2 Homo sapiens
0.00009
-
Dehydrolithocholic acid DD2 Homo sapiens
0.0006
-
Flufenamic acid DD2 Homo sapiens
0.0011
-
naproxen DD2 Homo sapiens
0.076
-
indomethacin DD2 Homo sapiens