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Literature summary for 1.3.1.2 extracted from
- Dihydropyrimidine dehydrogenase: a flavoprotein with four iron-sulfur clusters (2004), Biochim. Biophys. Acta, 1701, 61-74.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Sus scrofa |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| crystals diffract to 1.9 A | Sus scrofa |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2,6-Dihydroxypyridine | competitive vs. uracil | Sus scrofa |  |
| 5-Ethynyluracil | mechanism-based inhibition | Bos taurus | |
| 5-Iodo-uracil | mechanism-based inhibition | Bos taurus | |
| 5-Iodo-uracil | mechanism-based inactivator | Sus scrofa | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
| cytosol | - |
Rattus norvegicus | 5829 | - |
| cytosol | - |
Sus scrofa | 5829 | - |
| cytosol | - |
Bos taurus | 5829 | - |
| cytosol | - |
Cupriavidus necator | 5829 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Iron | each subunit contains 16 nonheme-irons in 4 [4Fe-4S] clusters | Sus scrofa | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 220000 | - |
- |
Sus scrofa |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5,6-dihydrouracil + NADP+ | Homo sapiens | first and rate-limiting enzyme in the three-step pathway for the degradation of uracil | uracil + NADPH | - |
? | |
| 5,6-dihydrouracil + NADP+ | Rattus norvegicus | first and rate-limiting enzyme in the three-step pathway for the degradation of uracil | uracil + NADPH | - |
? | |
| 5,6-dihydrouracil + NADP+ | Sus scrofa | first and rate-limiting enzyme in the three-step pathway for the degradation of uracil | uracil + NADPH | - |
? | |
| 5,6-dihydrouracil + NADP+ | Bos taurus | first and rate-limiting enzyme in the three-step pathway for the degradation of uracil | uracil + NADPH | - |
? | |
| 5,6-dihydrouracil + NADP+ | Cupriavidus necator | first and rate-limiting enzyme in the three-step pathway for the degradation of uracil | uracil + NADPH | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Cupriavidus necator | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
| Sus scrofa | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
- |
Rattus norvegicus |
- |
Sus scrofa |
- |
Bos taurus |
- |
Cupriavidus necator |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
| liver | - |
Sus scrofa | - |
| liver | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5,6-dihydrouracil + NADP+ | - |
Homo sapiens | uracil + NADPH | - |
? | |
| 5,6-dihydrouracil + NADP+ | - |
Rattus norvegicus | uracil + NADPH | - |
? | |
| 5,6-dihydrouracil + NADP+ | - |
Sus scrofa | uracil + NADPH | - |
? | |
| 5,6-dihydrouracil + NADP+ | - |
Bos taurus | uracil + NADPH | - |
? | |
| 5,6-dihydrouracil + NADP+ | - |
Cupriavidus necator | uracil + NADPH | - |
? | |
| 5,6-dihydrouracil + NADP+ | first and rate-limiting enzyme in the three-step pathway for the degradation of uracil | Homo sapiens | uracil + NADPH | - |
? | |
| 5,6-dihydrouracil + NADP+ | first and rate-limiting enzyme in the three-step pathway for the degradation of uracil | Rattus norvegicus | uracil + NADPH | - |
? | |
| 5,6-dihydrouracil + NADP+ | first and rate-limiting enzyme in the three-step pathway for the degradation of uracil | Sus scrofa | uracil + NADPH | - |
? | |
| 5,6-dihydrouracil + NADP+ | first and rate-limiting enzyme in the three-step pathway for the degradation of uracil | Bos taurus | uracil + NADPH | - |
? | |
| 5,6-dihydrouracil + NADP+ | first and rate-limiting enzyme in the three-step pathway for the degradation of uracil | Cupriavidus necator | uracil + NADPH | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | - |
Sus scrofa |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DPD | - |
Homo sapiens |
| DPD | - |
Rattus norvegicus |
| DPD | - |
Sus scrofa |
| DPD | - |
Bos taurus |
| DPD | - |
Cupriavidus necator |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | 1 FAD per subunit | Sus scrofa | |
| FMN | 1 FMN per subunit | Sus scrofa | |
| NADP+ | - |
Homo sapiens | |
| NADP+ | - |
Rattus norvegicus | |
| NADP+ | - |
Sus scrofa | |
| NADP+ | - |
Bos taurus | |
| NADP+ | - |
Cupriavidus necator | |
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Release 2023.1 (January 2023)
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