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Literature summary for 1.3.1.2 extracted from
- Stereochemistry of NADPH oxidation by dihydropyrimidine dehydrogenase from pig liver (1992), Biochem. Biophys. Res. Commun., 182, 609-616.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | rate limiting enzyme for detoxification of exogenous fluoropyrimidines, antitumor drug design | Sus scrofa |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sus scrofa | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Sus scrofa |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| 5,6-dihydrouracil + NADP+ = uracil + NADPH + H+ | abstraction of pro-S hydrogen of NADPH and thus B-side stereospecific class dehydrogenase | Sus scrofa |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Sus scrofa | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| uracil + NADPH | - |
Sus scrofa | 5,6-dihydrouracil + NADP+ | - |
? |  |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | strictly dependent on | Sus scrofa | |
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