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Literature summary for 1.3.1.2 extracted from

  • Grisolia, S.; Cardoso, S.S.
    The purification and properties of hydropyrimidine dehydrogenase (1957), Biochim. Biophys. Acta, 25, 430-431.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
thymine + NADPH Bos taurus
-
dihydrothymine + NADP+
-
r
uracil + NADPH Bos taurus
-
5,6-dihydrouracil + NADP+
-
r

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Bos taurus
2.2
-
substrate hydrothymine Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,6-dihydrouracil + NADP+
-
Bos taurus uracil + NADPH
-
r
5-bromouracil + NADPH
-
Bos taurus 5-bromo-5,6-dihydrouracil + NADP+
-
r
5-fluorouracil + NADPH + H+
-
Bos taurus 5-fluoro-5,6-dihydrouracil + NADP+
-
?
5-iodouracil + NADPH
-
Bos taurus 5-iodo-5,6-dihydrouracil + NADP+
-
r
dihydrothymine + NADP+
-
Bos taurus thymine + NADPH
-
r
hydrouridylic acid + NADPH low activity Bos taurus ?
-
?
thymine + NADPH
-
Bos taurus dihydrothymine + NADP+
-
r
uracil + NADPH
-
Bos taurus 5,6-dihydrouracil + NADP+
-
r

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
-
Bos taurus

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Bos taurus
NADPH
-
Bos taurus