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Literature summary for 1.3.1.2 extracted from

  • Milano, G.; Fischel, J.L.; Etienne, M.C.; Renee, N.; Formento, P.; Thyss, A.; Gaspard, M.H.; Thill, L.; Cupissol, D.
    Inhibition of dihydropyrimidine dehydrogenase by alpha-interferon: Experimental data on human tumor cell lines (1994), Cancer Chemother. Pharmacol., 34, 147-152.
    View publication on PubMed

Application

Application Comment Organism
medicine target for inhibitor design to enhance the cytotoxical effect of 5-fluorouracil in tumor cells by inhibiting the DPD activity with 5-fluorouracil as substrate Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
alpha-2a-interferon cell lines CAL 27, CAL 33, CAL 51, CAL 7, PANC 3 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5-fluorouracil + NADPH + H+ Homo sapiens
-
5-fluoro-5,6-dihydrouracil + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
CAL-27 cell
-
Homo sapiens
-
CAL-33 cell
-
Homo sapiens
-
CAL-51 cell
-
Homo sapiens
-
carcinoma cell cancer cell line CAL 7 Homo sapiens
-
PANC-3 cell
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.118
-
cell line CAL 27 Homo sapiens
0.122
-
cell line CAL 7 Homo sapiens
0.184
-
cell line CAL 33 Homo sapiens
0.265
-
cell line PANC 3 Homo sapiens
0.318
-
cell line CAL 51 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-fluorouracil + NADPH + H+
-
Homo sapiens 5-fluoro-5,6-dihydrouracil + NADP+
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens