Cloned (Comment) | Organism |
---|---|
expression in HEK-293T cell | Homo sapiens |
expression in HEK-293T cell | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000085 | - |
(9E)-9-nitrooctadec-9-enoic acid | pH 7.0, temperature not specified in the publication | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(9E)-9-nitrooctadec-9-enoic acid + NADPH + H+ | - |
Homo sapiens | 9-nitrostearic acid + NADP+ | - |
r | |
10-nitrooctadec-9-enoic acid + NADPH + H+ | - |
Homo sapiens | 10-nitrostearic acid + NADP+ | - |
? | |
10-nitrooctadec-9-enoic acid + NADPH + H+ | - |
Rattus norvegicus | 10-nitrostearic acid + NADP+ | - |
? | |
9-nitrooctadec-9-enoic acid + NADPH + H+ | - |
Homo sapiens | 9-nitrostearic acid + NADP+ | - |
? | |
9-nitrooctadec-9-enoic acid + NADPH + H+ | - |
Rattus norvegicus | 9-nitrostearic acid + NADP+ | - |
? | |
additional information | enzyme is specific for the reduction of the nitroalkene moiety, yielding saturated non-electrophilic products | Homo sapiens | ? | - |
? | |
additional information | enzyme is specific for the reduction of the nitroalkene moiety, yielding saturated non-electrophilic products | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
prostaglandin reductase-1 | - |
Homo sapiens |
prostaglandin reductase-1 | - |
Rattus norvegicus |
PtGR-1 | - |
Homo sapiens |
PtGR-1 | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | NADPH is preferred over NADH | Homo sapiens | |
NADH | NADPH is preferred over NADH | Rattus norvegicus | |
NADPH | NADPH is preferred over NADH | Homo sapiens | |
NADPH | NADPH is preferred over NADH | Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
physiological function | overexpression of prostaglandin reductase-1 in HEK-293T cells promotes nitroalkene metabolism to inactive nitroalkanes, an effect that abrogates the Nrf2-dependent induction of heme oxygenase-1 expression by nitro-oleic acid | Homo sapiens |
physiological function | overexpression of prostaglandin reductase-1 in HEK-293T cells promotes nitroalkene metabolism to inactive nitroalkanes, an effect that abrogates the Nrf2-dependent induction of heme oxygenase-1 expression by nitro-oleic acid | Rattus norvegicus |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
81 | - |
(9E)-9-nitrooctadec-9-enoic acid | pH 7.0, temperature not specified in the publication | Homo sapiens |