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Literature summary for 1.3.1.12 extracted from
- Prephenate dehydrogenase (monofunctional) (1987), Methods Enzymol., 142, 503-507.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4-hydroxyphenylpyruvate | - |
Bacillus subtilis |  |
| 4-hydroxyphenylpyruvate | - |
Cupriavidus necator | |
| chorismate | - |
Bacillus subtilis | |
| L-phenylalanine | - |
Bacillus subtilis | |
| L-tryptophan | - |
Bacillus subtilis | |
| L-tyrosine | - |
Bacillus subtilis | |
| L-tyrosine | - |
Cupriavidus necator | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.045 | 0.09 | prephenate | - |
Cupriavidus necator | |
| 0.045 | 0.09 | prephenate | - |
Xanthomonas campestris | |
| 2 | - |
prephenate | - |
Bacillus subtilis | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| prephenate + NAD+ | Bacillus subtilis | biosynthesis of L-tyrosine | 4-hydroxyphenylpyruvate + NADH + CO2 | - |
? | |
| prephenate + NAD+ | Cupriavidus necator | biosynthesis of L-tyrosine | 4-hydroxyphenylpyruvate + NADH + CO2 | - |
? | |
| prephenate + NAD+ | Xanthomonas campestris | biosynthesis of L-tyrosine | 4-hydroxyphenylpyruvate + NADH + CO2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bacillus subtilis | - |
- |
- |
| Cupriavidus necator | - |
basonym Alcaligenes eutrophus | - |
| Xanthomonas campestris | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Cupriavidus necator |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 8.9 | - |
- |
Cupriavidus necator |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| prephenate + NAD+ | - |
Bacillus subtilis | 4-hydroxyphenylpyruvate + NADH + CO2 | - |
? | |
| prephenate + NAD+ | - |
Cupriavidus necator | 4-hydroxyphenylpyruvate + NADH + CO2 | - |
? | |
| prephenate + NAD+ | - |
Xanthomonas campestris | 4-hydroxyphenylpyruvate + NADH + CO2 | - |
? | |
| prephenate + NAD+ | biosynthesis of L-tyrosine | Bacillus subtilis | 4-hydroxyphenylpyruvate + NADH + CO2 | - |
? | |
| prephenate + NAD+ | biosynthesis of L-tyrosine | Cupriavidus necator | 4-hydroxyphenylpyruvate + NADH + CO2 | - |
? | |
| prephenate + NAD+ | biosynthesis of L-tyrosine | Xanthomonas campestris | 4-hydroxyphenylpyruvate + NADH + CO2 | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Bacillus subtilis | |
| NAD+ | - |
Xanthomonas campestris | |
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Release 2023.1 (January 2023)
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