Application | Comment | Organism |
---|---|---|
drug development | the bacterial enoyl-ACP reductase is a target for antibacterial drug development | Staphylococcus aureus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
aquastatin A | a natural inhibitor from the fungus Sporothrix sp. strain FN611, mixed-type inhibition against FabI with respect to the substrate trans-2-octenoyl N-acetylcysteamine and NADPH, prevents the growth of Staphylococcus aureus and methicillin-resistant Staphylococcus aureus with minimum inhibitory concentration of 0.016-0.032 mg/ml, overview | Staphylococcus aureus | |
degalactosylated aquastatin A | a natural inhibitor from the fungus Sporothrix sp. strain FN611 | Staphylococcus aureus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Staphylococcus aureus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | activity measurement by reduction of the trans-2-octenoyl N-acetylcysteamine as substrate and NADPH as cofactor | Staphylococcus aureus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
enoyl-ACP reductase | - |
Staphylococcus aureus |
enoyl-acyl carrier protein reductase | - |
Staphylococcus aureus |
FabI | - |
Staphylococcus aureus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Staphylococcus aureus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.5 | - |
assay at | Staphylococcus aureus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Staphylococcus aureus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0014 | - |
aquastatin A | pH 6.5, 30°C, versus NADPH | Staphylococcus aureus | |
0.00161 | - |
aquastatin A | pH 6.5, 30°C, versus trans-2-octenoyl N-acetylcysteamine | Staphylococcus aureus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0032 | - |
FabI, pH 6.5, 30°C | Staphylococcus aureus | aquastatin A | |
0.0034 | - |
FabI, pH 6.5, 30°C | Staphylococcus aureus | degalactosylated aquastatin A |