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Literature summary for 1.21.99.4 extracted from

  • Aoki, T.; Tsunekawa, K.; Araki, O.; Ogiwara, T.; Nara, M.; Sumino, H.; Kimura, T.; Murakami, M.
    Type 2 iodothyronine deiodinase activity is required for rapid stimulation of PI3K by thyroxine in human umbilical vein endothelial cells (2015), Endocrinology, 156, 4312-4324.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
(Bu)2cAMP type 2 iodothyronine deiodinase is significantly stimulated by (Bu)2cAMP Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9C0K2
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HUVEC cell expression of type 2 iodothyronine deiodinase D2, which converts T4 to T3, and TR1 in HUVECs Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-thyroxine + reduced acceptor
-
Homo sapiens 3,3',5-triiodo-L-thyronine + iodide + acceptor + H+
-
?

General Information

General Information Comment Organism
physiological function the blockade of iodothyronine deiodinase D2 activity abolishes Akt phosphorylation, Rac activation, and cell migration induced by thyroxine but not by 3,3',5-triiodo-L-thyronine Homo sapiens