Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-thyroxine + AH2 | Mus musculus | - |
3,5,3'-triiodo-L-thyronine + iodide + A + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
osteoblast | the enzyme is restricted to mature primary osteoblasts | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-thyroxine + AH2 | - |
Mus musculus | 3,5,3'-triiodo-L-thyronine + iodide + A + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
type 2 iodothyronine deiodinase | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
dithiothreitol | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | bones from adult type 2 iodothyronine deiodinase-knockout mice have reduced toughness and are brittle, displaying an increased susceptibility to fracture. This phenotype is characterized by a 50% reduction in bone formation and a generalized increase in skeletal mineralization | Mus musculus |
physiological function | type 2 iodothyronine deiodinase plays a role in the optimization of bone strength and mineralization and is essential for normal osteoblast function | Mus musculus |