Activating Compound | Comment | Organism | Structure |
---|---|---|---|
thyroid hormone | - |
Mus musculus |
Cloned (Comment) | Organism |
---|---|
a promoter reporter gene for a luciferase assay is constructed | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
amiodarone | - |
Mus musculus | |
propylthiouracil | - |
Mus musculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
selenium | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-thyroxine + AH2 | Mus musculus | isoenzyme Dio1 | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | - |
? | |
L-thyroxine + AH2 | Mus musculus | - |
3,5,3'-triiodo-L-thyronine + iodide + A + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q61153 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Mus musculus | - |
liver | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-thyroxine + AH2 | isoenzyme Dio1 | Mus musculus | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | - |
? | |
L-thyroxine + AH2 | - |
Mus musculus | 3,5,3'-triiodo-L-thyronine + iodide + A + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DIO1 | - |
Mus musculus |
type 1 iodothyronine deiodinase | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
activity assay | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.2 | - |
activity assay | Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | expression of the Dio1 gene is dependent on HNF4alpha expression, the Dio1 promoter is directly regulated by HNF4alpha | down |
Mus musculus | expression of the Dio1 gene is dependent on HNF4alpha expression, the Dio1 promoter is directly regulated by HNF4alpha, the Krüppel-like transcription factor 9, KLF9, functions together with HNF4alpha and GATA4 to synergistically activate the promoter through direct interaction between these transcriptional factors | up |