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Literature summary for 1.21.99.4 extracted from

  • Boelen, A.; Kwakkel, J.; Wieland, C.W.; St Germain, D.L.; Fliers, E.; Hernandez, A.
    Impaired bacterial clearance in type 3 deiodinase-deficient mice infected with Streptococcus pneumoniae (2009), Endocrinology, 150, 1984-1990.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.21.99.4

Organism

Organism UniProt Comment Textmining
Mus musculus Q61153 wild-type and type 3 deiodinase knockout mice, infected with Streptococcus pneumoniae
-
Mus musculus Q9Z148 wild-type and type 3 deiodinase knockout mice, infected with Streptococcus pneumoniae
-

Source Tissue

Source Tissue Comment Organism Textmining
hypothalamus
-
 Mus musculus
-
liver
-
 Mus musculus
-
pituicyte
-
 Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0000000005
-
 pituitary type 2 deiodinase activity, type 3 deiodinase knockout mice after infection with Streptococcus pneumoniae Mus musculus
0.00000000075
-
 pituitary type 2 deiodinase activity, wild-type mice after infection with Streptococcus pneumoniae Mus musculus
0.0000000014
-
 value about, pituitary type 2 deiodinase activity, type 3 deiodinase knockout mice Mus musculus
0.0000000015
-
 value about, pituitary type 2 deiodinase activity, wild-type mice Mus musculus
0.00000075
-
 type 3 deiodinase knockout mice Mus musculus
0.000001
-
 type 3 deiodinase knockout mice after infection with Streptococcus pneumoniae Mus musculus
0.00000125
-
 wild-type mice after infection with Streptococcus pneumoniae Mus musculus
0.000002
-
 wild-type mice Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3,5,3'-triiodo-L-thyronine + iodide + A + H+ assay at pH 7.2 Mus musculus L-thyroxine + AH2
-
 ?
L-thyroxine + AH2 assay at pH 7.2 Mus musculus 3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
 ?

Synonyms

Synonyms Comment Organism
type 1 deiodinase
-
 Mus musculus
type 2 deiodinase
-
 Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
 assay at Mus musculus

Expression

Organism Comment Expression
Mus musculus decrease of liver type 1 deiodinase levels after infection only in wild-type mice, low expression levels in type 3 deiodinase knockout mice down
Mus musculus decrease of pituitary type 2 deiodinase levels after infection down