Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.21.99.4 extracted from

  • Kuiper, G.G.; Wassen, F.; Klootwijk, W.; Van Toor, H.; Kaptein, E.; Visser, T.J.
    Molecular basis for the substrate selectivity of cat type I iodothyronine deiodinase (2003), Endocrinology, 144, 5411-5421.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in COS cells Felis catus

Inhibitors

Inhibitors Comment Organism Structure
propylthiouracil native and recombinant enzyme, IC50: 0.005-0.01 mM Felis catus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0007
-
sulfated reverse triiodothyronine wild-type enzyme Felis catus
0.015
-
reverse triiodothyronine wild-type enzyme Felis catus

Organism

Organism UniProt Comment Textmining
Felis catus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
reverse triiodothyronine + AH2
-
Felis catus diiodothyronine + iodide + A + H+
-
?
sulfated reverse triiodothyronine + AH2
-
Felis catus diiodothyronine + iodide + A + H+ + ?
-
?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.005 0.01 native and recombinant enzyme, IC50: 0.005-0.01 mM Felis catus propylthiouracil